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Cancer Epidemiol. 2013 Aug;37(4):434-9. doi: 10.1016/j.canep.2013.02.010. Epub 2013 Mar 21.

Telomere length and risk of melanoma, squamous cell carcinoma, and basal cell carcinoma.

Author information

1
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA. gabriella.anic@moffitt.org

Abstract

BACKGROUND:

Telomeres help maintain chromosomal structure and may influence tumorigenesis. We examined the association between telomere length and skin cancer in a clinic-based case-control study of 198 melanoma cases, 136 squamous cell carcinoma (SCC) cases, 185 basal cell carcinoma (BCC) cases, and 372 healthy controls.

METHODS:

Cases were histologically confirmed patients treated at the Moffitt Cancer Center and University of South Florida Dermatology Clinic in Tampa, FL. Controls self-reported no history of cancer and underwent a skin cancer screening exam at study enrollment to rule out the presence of skin cancer. Quantitative real time PCR was used to measure telomere length in peripheral blood samples.

RESULTS:

Melanoma patients had longer telomeres than controls (odds ratio (OR)=3.75; 95% confidence interval (CI): 2.02-6.94 for highest versus lowest tertile) (P for trend=<0.0001). In contrast, longer telomere length was significantly inversely associated with SCC (OR=0.01; 95% CI: 0.00-0.05 for highest versus lowest tertile) (P for trend=<0.0001) and BCC (OR=0.10; 95% CI: 0.06-0.19 for highest versus lowest tertile) (P for trend=<0.0001).

CONCLUSION:

Telomere length may be involved in the development of skin cancer, although the effect on cancer risk differs for melanoma and non-melanoma carcinomas. Our findings suggest that long telomere length is positively associated with melanoma while inversely associated with SCC and BCC.

PMID:
23523330
PMCID:
PMC3679277
DOI:
10.1016/j.canep.2013.02.010
[Indexed for MEDLINE]
Free PMC Article
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