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Curr Opin Chem Biol. 2013 Apr;17(2):261-70. doi: 10.1016/j.cbpa.2013.02.017. Epub 2013 Mar 20.

CC bond formation using ThDP-dependent lyases.

Author information

1
Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany. michael.mueller@pharmazie.uni-freiburg.de

Abstract

The present review summarizes recent achievements in enzymatic thiamine catalysis during the past three years. With well-established enzymes such as BAL, PDC and TK new reactions have been identified and respective variants were prepared, which enable access to stereoisomeric products. Further we highlight recent progress with 'new' ThDP-dependent enzymes like MenD and PigD, which catalyze the Stetter-like 1,4 addition of aldehydes and YerE, which is the first known ThDP-dependent enzyme accepting ketones as acceptors.

PMID:
23523314
DOI:
10.1016/j.cbpa.2013.02.017
[Indexed for MEDLINE]

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