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Curr Opin Pharmacol. 2013 Jun;13(3):470-5. doi: 10.1016/j.coph.2013.03.004. Epub 2013 Mar 20.

How safe are anti-rheumatic drugs during pregnancy?

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National Center of Pregnancy and Rheumatic Disease, Department of Rheumatology, University Hospital of Trondheim, Norway.


Rheumatic diseases may be active during pregnancy necessitating drug treatment in order to control maternal disease activity and ensure a successful pregnancy outcome. The present literature survey of the last 2 years does not profoundly change the recommendations given in recent reviews: the teratogenic drugs cyclophosphamide, methotrexate, mycophenolate mofetil, and biologics without or with few pregnancy data must be withdrawn before a planned pregnancy. Leflunomide has up to date not shown to be a human teratogen. Drugs that can be used throughout pregnancy include corticosteroids, sulfasalazine, antimalarials, cyclosporine, tacrolimus and azathioprine. Among biological drugs extended pregnancy experience exists only for TNF-inhibitors. The effect of immunosuppressive drugs and biologics on male reproductive function is only partly known.

[Indexed for MEDLINE]

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