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Curr Opin Pharmacol. 2013 Jun;13(3):470-5. doi: 10.1016/j.coph.2013.03.004. Epub 2013 Mar 20.

How safe are anti-rheumatic drugs during pregnancy?

Author information

1
National Center of Pregnancy and Rheumatic Disease, Department of Rheumatology, University Hospital of Trondheim, Norway. monika.ostensen@gmail.com

Abstract

Rheumatic diseases may be active during pregnancy necessitating drug treatment in order to control maternal disease activity and ensure a successful pregnancy outcome. The present literature survey of the last 2 years does not profoundly change the recommendations given in recent reviews: the teratogenic drugs cyclophosphamide, methotrexate, mycophenolate mofetil, and biologics without or with few pregnancy data must be withdrawn before a planned pregnancy. Leflunomide has up to date not shown to be a human teratogen. Drugs that can be used throughout pregnancy include corticosteroids, sulfasalazine, antimalarials, cyclosporine, tacrolimus and azathioprine. Among biological drugs extended pregnancy experience exists only for TNF-inhibitors. The effect of immunosuppressive drugs and biologics on male reproductive function is only partly known.

PMID:
23522967
DOI:
10.1016/j.coph.2013.03.004
[Indexed for MEDLINE]

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