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J Endod. 2013 Apr;39(4):467-72. doi: 10.1016/j.joen.2012.11.023. Epub 2013 Jan 11.

Biological effects and washout resistance of a newly developed fast-setting pozzolan cement.

Author information

1
Department of Conservative Dentistry, Wonkwang University, Iksan, Korea.

Abstract

INTRODUCTION:

Mineral trioxide aggregate has been widely used as a retrograde filling material. The aim of this study was to evaluate the biological effects of a newly developed fast-setting, mineral trioxide aggregate-derived pozzolan cement (Endocem). Furthermore, we explored whether this cement is resistant to washout in comparison with ProRoot.

METHODS:

Biocompatibility was evaluated on the basis of cell morphology and a viability test. The expression of osteogenic genes was evaluated by performing real-time polymerase chain reaction, and calcified nodule formation was assessed by alizarin red S staining. The setting time was measured, and washout testing was performed by placing the material into fetal bovine serum.

RESULTS:

The biocompatibility and osteogenicity of Endocem were similar to those of ProRoot. Moreover, Endocem showed a higher resistance to washout than ProRoot did.

CONCLUSIONS:

These results suggest that Endocem can be used as an available retrograde filling material because it sets faster and shows similar biological effects when compared with ProRoot.

PMID:
23522538
DOI:
10.1016/j.joen.2012.11.023
[Indexed for MEDLINE]

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