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Lipids Health Dis. 2013 Mar 22;12:39. doi: 10.1186/1476-511X-12-39.

Associations of SAA1 gene polymorphism with lipid lelvels and osteoporosis in Chinese women.

Author information

1
Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. fengzhengping_f@yeah.net

Abstract

BACKGROUND:

The development of osteoporosis is associated with several risk factors, such as genetic polymorphisms and enviromental factors. This study assessed the correlation between SAA1 gene rs12218 polymorphism and HDL-C lelvels and osteoporosis in a population of Chinese women.

METHODS:

A total of 387 postmenopausal female patients who were diagnosed with osteoporosis (case group) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 307 females with no osteoporosis (control group) were included in this study. Correlations between SAA1 gene rs12218 polymorphism and osteoporosis and HDL-C level were investigated through the identification of SAA1 gene rs12218 polymorphism genotypes using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTS:

The TT genotype of rs12218 was more frequently in osteoporosis patients than in control subjects (P <0.001). And the rs12218 was found to be associated with plasma TG, HDL-C, LDL-C, and BMD levels in osteoporosis patients (P<0.05).

CONCLUSIONS:

The present results indicate that both osteoporosis and lipids levels are associated with the TT genotype of rs12218 in the human SAA1 gene.

PMID:
23522429
PMCID:
PMC3702468
DOI:
10.1186/1476-511X-12-39
[Indexed for MEDLINE]
Free PMC Article

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