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Neuron. 2013 Mar 20;77(6):1039-46. doi: 10.1016/j.neuron.2013.01.013.

Regulation of postsynaptic retrograde signaling by presynaptic exosome release.

Author information

1
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Abstract

Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms that trigger the release of retrograde signals and the role of presynaptic cells in this signaling event are unknown. Here we show that a retrograde signal mediated by Synaptotagmin 4 (Syt4) is transmitted to the postsynaptic cell through anterograde delivery of Syt4 via exosomes. Thus, by transferring an essential component of retrograde signaling through exosomes, presynaptic cells enable retrograde signaling.

PMID:
23522040
PMCID:
PMC3626103
DOI:
10.1016/j.neuron.2013.01.013
[Indexed for MEDLINE]
Free PMC Article

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