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Chem Biol. 2013 Mar 21;20(3):351-9. doi: 10.1016/j.chembiol.2012.12.009.

Discovery of peptoid ligands for anti-aquaporin 4 antibodies.

Author information

1
Departments of Chemistry and Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

Abstract

Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system. In most NMO patients, autoantibodies to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes. Here, we apply recently developed chemical library screening technology to identify a synthetic peptoid that binds anti-AQP4 antibodies in the serum of NMO patients. This finding validates, in a well-defined human disease, that synthetic, unnatural ligands for the antigen-binding site of a disease-linked antibody can be isolated by high-throughput screening.

PMID:
23521793
PMCID:
PMC3640264
DOI:
10.1016/j.chembiol.2012.12.009
[Indexed for MEDLINE]
Free PMC Article

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