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J Med Chem. 2013 Apr 25;56(8):3310-7. doi: 10.1021/jm400049z. Epub 2013 Apr 10.

Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.

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1
School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

Abstract

A range of 2-aminophenoxazin-3-ones has been prepared by oxidative cyclocondensation of 2-aminophenols, including the natural products exfoliazone and chandrananimycin A, both synthesized for the first time. The compounds were evaluated for their ability to inhibit indoleamine 2,3-dioxygenase. Compounds containing additional electron-withdrawing carboxylate groups, such as cinnabarinic acid, showed modest inhibitory activity with a dose response.

PMID:
23521768
DOI:
10.1021/jm400049z
[Indexed for MEDLINE]

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