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Scand J Infect Dis. 2013 Jul;45(7):526-30. doi: 10.3109/00365548.2013.776700. Epub 2013 Mar 22.

Cerebrospinal fluid chemokine CXCL13 in the diagnosis of neuroborreliosis in children.

Author information

1
Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland.

Abstract

BACKGROUND:

The diagnosis of Lyme neuroborreliosis (LNB) requires laboratory confirmation because neurological symptoms indicative of LNB are not specific. Recent studies have suggested that a chemokine, CXCL13, could have an important role in the diagnosis of LNB. The aim of this study was to assess CXCL13 levels in the cerebrospinal fluid (CSF) of children with LNB.

METHODS:

CSF samples were available for 57 children with symptoms indicative of LNB. Based on the presence of anti-flagella antibodies and pleocytosis in CSF, patients were divided into 3 different groups: confirmed LNB (n = 24), possible LNB (n = 16), and non-LNB (n = 17). CXCL13 levels were determined with a commercial kit (Quantikine).

RESULTS:

All 24 patients with confirmed LNB had elevated CXCL13 levels in CSF. Elevated CXCL13 was also observed in the majority of patients without anti-flagella antibodies in the CSF (possible LNB). Of the 17 non-LNB and 50 control samples, 1 was positive.

CONCLUSIONS:

In LNB, the production of CXCL13 in CSF seems to precede antibody production. Assessment of CSF CXCL13 may improve the diagnostics for children with possible LNB.

PMID:
23521134
DOI:
10.3109/00365548.2013.776700
[Indexed for MEDLINE]

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