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Channels (Austin). 2013 May-Jun;7(3):135-45. doi: 10.4161/chan.24228. Epub 2013 Mar 21.

Ion channels and information processing in GnRH neuron dendrites.

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1
Department of Biology, University of Texas San Antonio, San Antonio, TX, USA.

Abstract

Recent findings indicate that a majority of action potentials originate from dendrites of GnRH neurons. This localization of the dendrite as the principle site of action potential initiation has sparked considerable interest in the nature of ionic channels throughout GnRH neurons. This paper will review the ionic conductances described within GnRH neurons and their implications for physiological output, such as sensitivity to steroids and diurnal state. To date, a majority of information regarding ionic conductances in GnRH neurons pertains to somata and the first 50-100 µm of dendrite length. Thus, unraveling the tapestry created by the nature and distribution of dendritic conductances in GnRH neurons lies at the forefront of understanding the control of reproductive hormone secretion.

KEYWORDS:

GnRH neurons; conductance; dendrites; estradiol; hypothalamus; modeling; morphology; puberty

PMID:
23519241
PMCID:
PMC3710340
DOI:
10.4161/chan.24228
[Indexed for MEDLINE]
Free PMC Article
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