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Curr Biol. 2013 Mar 18;23(6):R236-9. doi: 10.1016/j.cub.2013.02.028.

Chromosome segregation: disarming the protector.

Author information

1
Max F. Perutz Laboratories, Department of Chromosome Biology, University of Vienna, Dr. Bohr-Gasse 1, 1030 Vienna, Austria.

Abstract

One of the key features of meiosis is that shugoshin in complex with protein phosphatase 2A (PP2A) protects centromeric cohesin during meiosis I, but not during meiosis II. A new model suggests that a PP2A inhibitor mediates deprotection of centromeric cohesin during meiosis II.

PMID:
23518053
PMCID:
PMC3605575
DOI:
10.1016/j.cub.2013.02.028
[Indexed for MEDLINE]
Free PMC Article

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