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Annu Rev Immunol. 2013;31:563-604. doi: 10.1146/annurev-immunol-020711-074950.

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.

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1
Department of Oncological Sciences, Mount Sinai Medical School, New York, NY 10029, USA. Miriam.merad@mssm.edu

Abstract

Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.

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