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PLoS One. 2013;8(3):e58506. doi: 10.1371/journal.pone.0058506. Epub 2013 Mar 13.

NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study.

Author information

1
Hypertension in Africa Research Team (HART), Department of Physiology, North-West University, Potchefstroom, North-West Province, South Africa. ruan.kruger@nwu.ac.za

Abstract

OBJECTIVE AND DESIGN:

This cross-sectional study aimed to investigate associations between a marker of cardiac strain, the N-terminal prohormone B-type natriuretic peptide (NT-proBNP), and inflammation as reflected by either a conventional or novel inflammatory marker in a bi-ethnic South African cohort.

METHODS AND SUBJECTS:

We measured NT-proBNP, C-reactive protein (CRP) and plasma-soluble urokinase plasminogen activator receptor (suPAR) levels along with conventional biomarkers in black (n = 117) and white (n = 116) men.

RESULTS:

NT-proBNP, CRP and suPAR levels were higher in black compared to white men. NT-proBNP was significantly associated with both CRP (r = 0.38; p = 0.001) and suPAR (r = 0.42; p<0.001) in black men only. After full adjustment in multiple regression analyses, the above associations of NT-proBNP with CRP (β = 0.199; p = 0.018) and suPAR (β = 0.257; p<0.01) were confirmed in black men.

CONCLUSION:

These results suggest that a low-grade inflammatory state as reflected by both a conventional and novel marker of inflammation may contribute to higher cardiovascular risk as reflected by the associations obtained with a marker of cardiac strain in black South African men.

PMID:
23516493
PMCID:
PMC3596271
DOI:
10.1371/journal.pone.0058506
[Indexed for MEDLINE]
Free PMC Article

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