Send to

Choose Destination
Cell Mol Life Sci. 2014 Jan;71(2):183-203. doi: 10.1007/s00018-013-1318-0. Epub 2013 Mar 21.

Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective.

Author information

Alimentary Pharmabiotic Centre, Department of Microbiology Biosciences Institute, University College Cork, National University of Ireland, Western Road, Cork, Ireland.


The human gut represents a highly complex ecosystem, which is densely colonized by a myriad of microorganisms that influence the physiology, immune function and health status of the host. Among the many members of the human gut microbiota, there are microorganisms that have co-evolved with their host and that are believed to exert health-promoting or probiotic effects. Probiotic bacteria isolated from the gut and other environments are commercially exploited, and although there is a growing list of health benefits provided by the consumption of such probiotics, their precise mechanisms of action have essentially remained elusive. Genomics approaches have provided exciting new opportunities for the identification of probiotic effector molecules that elicit specific responses to influence the physiology and immune function of their human host. In this review, we describe the current understanding of the intriguing relationships that exist between the human gut and key members of the gut microbiota such as bifidobacteria and lactobacilli, discussed here as prototypical groups of probiotic microorganisms.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center