Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Endocrinol (Lausanne). 2013 Mar 18;4:23. doi: 10.3389/fendo.2013.00023. eCollection 2013.

NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion.

Author information

1
Kanazawa University Kanazawa, Japan.

Abstract

Neuropeptide B/W receptor-1 (NPBWR1) and NPBWR2 had been known as orphan receptors GPR7 and 8, respectively. Endogenous peptide ligands of these receptors, neuropeptide B (NPB) and neuropeptide W (NPW), were identified in 2002 and 2003 (Fujii et al., 2002; Brezillon et al., 2003; Tanaka et al., 2003). These peptides have been implicated in regulation of feeding behavior, energy homeostasis, neuroendocrine function, and modulating inflammatory pain. In addition, strong and discrete expression of their receptors in the extended amygdala and bed nucleus of the stria terminalis suggests a potential role in regulating stress responses, emotion, anxiety, and fear. Recent studies of NPB/NPW using both pharmacological and phenotypic analyses of genetically engineered mice as well as a human study support this hypothesis.

KEYWORDS:

amygdala; emotions; hypothalamus; limbic system; neuropeptide B; neuropeptide W; pain

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center