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Nucleus. 2013 Mar-Apr;4(2):92-4. doi: 10.4161/nucl.24236. Epub 2013 Mar 1.

Gene loops and HDACs to promote transcription directionality.

Author information

1
Department of Cell Biology, NCCR Frontiers in Genetics, iGE3 and University of Geneva, Geneva, Switzerland.

Abstract

Gene loops have been described in different organisms from yeast to human and form through interaction between components of the transcription pre-initiation complex and Ssu72, a member of the 3' end cleavage and polyadenylation complex. A recent study by Tan-Wong et al. reports a new role for gene loops in promoting ORF transcription directionality from otherwise bidirectional promoters.

KEYWORDS:

antisense RNA; bidirectional promoters; gene loop; histone deacetylase; non-coding RNA

PMID:
23514951
PMCID:
PMC3621750
DOI:
10.4161/nucl.24236
[Indexed for MEDLINE]
Free PMC Article

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