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Thyroid Res. 2013 Mar 14;6 Suppl 1:S10. doi: 10.1186/1756-6614-6-S1-S10. Epub 2013 Mar 14.

Management of hyperparathyroidism (PHP) in MEN2 syndromes in Europe.

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1
Endocrine Unit, Evgenidion Hospital and Dept Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 11528 Athens, Greece. mani@otenet.gr.

Abstract

Hyperparathyroidism occurs in 20-30% of MEN2A syndrome patients. It is usually associated with mild disease and is frequently asymptomatic, especially in younger age. There is genotype/phenotype association and PHP is usually associated with codon 634 mutations; however association with more "rare" mutations has also been reported. The pathology of the parathyroid glands includes hyperplasia, adenoma or a combination of the two. The optimal surgical management of this entity has not been defined yet.

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