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Biochem Soc Trans. 2013 Apr;41(2):508-12. doi: 10.1042/BST20120238.

A model of the large-scale organization of chromatin.

Author information

1
Università di Napoli 'Federico II', Dipartimento di Scienze Fisiche, INFN Sezione di Napoli, CNR-SPIN, Complesso Universitario di Monte S. Angelo, Via Cintia, 80126 Napoli, Italy.

Abstract

In the cell nucleus, chromosomes have a complex spatial organization, spanning several length scales, which serves vital functional purposes. It is unknown, however, how their three-dimensional architecture is orchestrated. In the present article, we review the application of a model based on classical polymer physics, the strings and binders switch model, to explain the molecular mechanisms of chromatin self-organization. We explore the scenario where chromatin architecture is shaped and regulated by the interactions of chromosomes with diffusing DNA-binding factors via thermodynamics mechanisms and compare it with available experimental data.

PMID:
23514144
DOI:
10.1042/BST20120238
[Indexed for MEDLINE]
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