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F1000Prime Rep. 2013;5:5. doi: 10.12703/P5-5. Epub 2013 Mar 4.

Longevity and aging.

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1
Department of Pathology, University of Washington Seattle, WA 98195 USA ; Institute of Aging Research, Guangdong Medical College Dongguan 523808 China.

Abstract

Research into the biology of aging seeks to understand the basic mechanisms of aging, with the goal of extending the period of life spent free from chronic disease and disability. Aging results from molecular processes that are modulated by genetic and environmental parameters. At least some of these mechanisms of aging are broadly shared across eukaryotic species from yeast to mice, and likely humans, as well. Recent breakthroughs in aging-related research have identified conserved longevity factors, such as components of the insulin-like signaling pathway and the mechanistic target of rapamycin, and have suggested potential paths toward developing the first interventions to slow aging in humans.

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