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Obesity (Silver Spring). 2013 Dec;21(12):E592-8. doi: 10.1002/oby.20462. Epub 2013 Jun 22.

Metabolic consequences of the early onset of obesity in common marmoset monkeys.

Author information

1
Nutrition Laboratory, Conservation Ecology Center, Smithsonian Conservation Biology Institute, National Zoological Park, Washington, District of Columbia, USA; Research Department, American College of Obstetricians and Gynecologists, Washington, District of Columbia, USA.

Abstract

OBJECTIVE:

The common marmoset as a model of early obesity was assessed. The hypotheses that juvenile marmosets with excess adipose tissue will display higher fasting glucose, decreased insulin sensitivity, and decreased ability to clear glucose from the blood stream were tested.

DESIGN AND METHODS:

Normal and obese (body fat > 14%) common marmoset infants (N = 39) were followed up from birth until 1 year. Body fat was measured by quantitative magnetic resonance. Circulating glucose was measured by glucometer and insulin, adiponectin, and leptin by commercial assays. The quantitative insulin sensitivity check index (QUICKI; a measure of insulin sensitivity) was calculated for subjects with fasting glucose and insulin measures. Oral glucose tolerance tests (OGTTs) were conducted at 12 months on 35 subjects.

RESULTS:

At 6 months, obese subjects already had significantly lower insulin sensitivity (mean QUICKI = 0.378 ± 0.029 vs. 0.525 ± 0.019, N = 11, P = 0.003). By 12 months, obese subjects also had higher fasting glucose (129.3 ± 9.1 mg/dL vs. 106.1 ± 6.5 mg/dL, P = 0.042), and circulating adiponectin tended to be lower (P = 0.057). Leptin was associated with percent body fat; however, birth weight also influenced circulating leptin. The OGTT results demonstrated that obese animals had a decreased ability to clear glucose.

CONCLUSIONS:

Early-onset obesity in marmosets results in impaired glucose homeostasis by 1 year.

PMID:
23512966
PMCID:
PMC3855166
DOI:
10.1002/oby.20462
[Indexed for MEDLINE]
Free PMC Article

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