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Schizophr Bull. 2013 Sep;39(5):962-5. doi: 10.1093/schbul/sbt034. Epub 2013 Mar 19.

Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery?

Author information

1
Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA. Mharrow@psych.uic.edu

Abstract

Antipsychotic medications are viewed as cornerstones for both the short-term and long-term treatment of schizophrenia. However, evidence on long-term (10 or more years) efficacy of antipsychotics is mixed. Double-blind discontinuation studies indicate significantly more relapses in unmedicated schizophrenia patients in the first 6-10 months, but also present some potentially paradoxical features. These issues are discussed.

KEYWORDS:

longitudinal studies; outcome; psychosis; unmedicated patients

PMID:
23512950
PMCID:
PMC3756791
DOI:
10.1093/schbul/sbt034
[Indexed for MEDLINE]
Free PMC Article
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