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Nat Rev Neurosci. 2013 Apr;14(4):293-304. doi: 10.1038/nrn3464.

Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders.

Author information

1
Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Blasco-Ibez 15, Valencia 46010, Spain. Rafael.Tabares@uv.es

Abstract

Inverse comorbidity is a lower-than-expected probability of disease occuring in individuals who have been diagnosed with other medical conditions. Emerging evidence points to inverse cancer comorbidity in people with certain CNS disorders. In this Opinion article, we discuss the evidence for this intriguing association and possible underlying mechanisms. We believe that this association is an invaluable opportunity to gain insight into the pathogenesis of these diseases, and understanding why certain individuals with CNS disorders are protected against many different types of cancer could help to develop new and improved treatments.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00756717 NCT00878189.

PMID:
23511909
DOI:
10.1038/nrn3464
[Indexed for MEDLINE]

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