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Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 May;115(5):624-9. doi: 10.1016/j.oooo.2012.12.014. Epub 2013 Mar 17.

Commercial mouthwashes are ineffective against oral MRSA biofilms.

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1
Institute of Healthcare Associated Infection, University of the West of Scotland, Ayr, UK.

Abstract

OBJECTIVE:

The aim of this study was to evaluate and compare the activity of oral mouthwashes against biofilm forms of MRSA isolated from the oral cavity and the bloodstream.

STUDY DESIGN:

The time-kill kinetics efficacy of 7 over-the-counter mouthwashes were tested against 28 clinical MRSA biofilm isolates for 0.5, 1 and 2 min.

RESULTS:

Treatments of MRSA biofilms formed by oral and bloodstream isolates were not significantly different, with mouthwashes displaying a rapid and modest anti-biofilm effect. None of the biofilm isolates were completely eradicated by the compounds tested, with a maximal killing of only approximately 70% shown by Corsodyl and Peroxyl. Maximum activity of all compounds tested was observed after 0.5 min. Fluorigard showed the poorest overall activity (57% reduction).

CONCLUSIONS:

MRSA colonize the oral cavity, and are more prevalent in institutionalized persons and the elderly. Over-the-counter mouthwashes are ineffective at killing MRSA biofilms, which has infection control implications.

PMID:
23510687
DOI:
10.1016/j.oooo.2012.12.014
[Indexed for MEDLINE]
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