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BMC Cell Biol. 2013 Mar 19;14:18. doi: 10.1186/1471-2121-14-18.

BMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause.

Abstract

BACKGROUND:

The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats.

RESULTS:

Cisplatin increased GC apoptosis from 0.59% to 13.04% in the control and cisplatin treatment groups, respectively, which was significantly reduced upon co-culture with BMSCs to 4.84%. Cisplatin treatment increased p21 and bax and decreased c-myc mRNA expression, which was reversed upon co-culture with BMSCs. As compared to young rats, increased apoptosis was observed in the perimenopausal rats (P < 0.001). After 3 months, the apoptosis rate in the BMSC group was significantly lower than that of the control group (P = 0.007).

CONCLUSIONS:

BMSC therapy may protect against GC apoptosis induced by cisplatin and perimenopause. Further studies are necessary to evaluate therapeutic efficacy of BMSCs.

PMID:
23510080
PMCID:
PMC3640998
DOI:
10.1186/1471-2121-14-18
[Indexed for MEDLINE]
Free PMC Article

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