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Biomed Res Int. 2013;2013:742149. doi: 10.1155/2013/742149. Epub 2013 Feb 13.

Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.

Author information

1
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland. daniel.lowicki@uj.edu.pl

Abstract

In this paper structural and microbiological studies on the ionophorous antibiotic monensin A and its derivatives have been collected. Monensin A is an ionophore which selectively complexes and transports sodium cation across lipid membranes, and therefore it shows a variety of biological properties. This antibiotic is commonly used as coccidiostat and nonhormonal growth promoter. The paper focuses on both the latest and earlier achievements concerning monensin A antimicrobial activity. The activities of monensin derivatives, including modifications of hydroxyl groups and carboxyl group, are also presented.

PMID:
23509771
PMCID:
PMC3586448
DOI:
10.1155/2013/742149
[Indexed for MEDLINE]
Free PMC Article

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