Format

Send to

Choose Destination
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 May-Jun;5(3):266-85. doi: 10.1002/wnan.1218. Epub 2013 Mar 18.

Long-range assembly of DNA into nanofibers and highly ordered networks.

Author information

1
Department of Chemistry, McGill University, Montreal, Quebec, Canada.

Abstract

Long-range assembly of DNA currently comprises both top-down and bottom-up methods. The top-down techniques consist of physical alignment of DNA and lithographic patterning to organize DNA on surfaces. The bottom-up approaches include lipid-and polymer-DNA co-assembly, the self-assembly of DNA amphiphiles, and the remarkably specific and versatile methods of DNA nanotechnology. DNA-based materials possess unprecedented molecular control and may offer innovative solutions in the fields of nanotechnology, sensing, nanomedicine, as well as optical and electronic devices. To realize the potential of these materials, a number of hurdles must be addressed. Bridging the gap between top-down fabrication and bottom-up assembly is of critical importance to the successful development of functional DNA-based technology. A profound understanding of both regimes is necessary to achieve this goal.

PMID:
23509022
DOI:
10.1002/wnan.1218
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center