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Nanoscale. 2013 Apr 21;5(8):3253-6. doi: 10.1039/c3nr00335c. Epub 2013 Mar 19.

Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging.

Author information

1
Stanford Molecular Imaging Program (MIPS), Department of Radiology, Stanford University, Stanford, CA 94305-5484, USA. xiongliqin@sjtu.edu.cn

Abstract

We report a simple, efficient synthesis of novel (18)F-labeled imaging agents based on YF3 nanoparticles. Targeting ligands and antitumor drug molecules can be introduced onto the YF3 nanoparticles in a one-pot synthesis. The (18)F-labeling reaction proceeds in aqueous solutions at room temperature with excellent radiolabeling yields (>80%) in a very short time (5-10 min). (18)F-labeled YF3 nanoparticles displayed high stability in mouse and human serum, and their application for mapping lymph nodes in live rats after local injection has also been demonstrated.

PMID:
23508229
PMCID:
PMC3645980
DOI:
10.1039/c3nr00335c
[Indexed for MEDLINE]
Free PMC Article
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