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Nat Immunol. 2013 Apr;14(4):320-6. doi: 10.1038/ni.2549.

Fishing for mammalian paradigms in the teleost immune system.

Author information

1
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. sunyer@vet.upenn.edu

Abstract

Recent years have witnessed a renaissance in the study of fish immune systems. Such studies have greatly expanded the knowledge of the evolution and diversification of vertebrate immune systems. Several findings in those studies have overturned old paradigms about the immune system and led to the discovery of novel aspects of mammalian immunity. Here I focus on how findings pertaining to immunity in teleost (bony) fish have led to major new insights about mammalian B cell function in innate and adaptive immunity. Additionally, I illustrate how the discovery of the most ancient mucosal immunoglobulin described thus far will help resolve unsettled paradigms of mammalian mucosal immunity.

PMID:
23507645
PMCID:
PMC4203445
DOI:
10.1038/ni.2549
[Indexed for MEDLINE]
Free PMC Article

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