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Schizophr Res. 2013 May;146(1-3):289-90. doi: 10.1016/j.schres.2013.02.021. Epub 2013 Mar 16.

Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia.

Author information

1
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA.

Abstract

Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders.

PMID:
23507357
PMCID:
PMC3650833
DOI:
10.1016/j.schres.2013.02.021
[Indexed for MEDLINE]
Free PMC Article

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