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Mol Aspects Med. 2013 Apr-Jun;34(2-3):516-28. doi: 10.1016/j.mam.2012.07.010.

SLC27 fatty acid transport proteins.

Author information

1
Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California Berkeley, CA, USA.

Abstract

The uptake and metabolism of long chain fatty acids (LCFA) are critical to many physiological and cellular processes. Aberrant accumulation or depletion of LCFA underlie the pathology of numerous metabolic diseases. Protein-mediated transport of LCFA has been proposed as the major mode of LCFA uptake and activation. Several proteins have been identified to be involved in LCFA uptake. This review focuses on the SLC27 family of fatty acid transport proteins, also known as FATPs, with an emphasis on the gain- and loss-of-function animal models that elucidate the functions of FATPs in vivo and how these transport proteins play a role in physiological and pathological situations.

PMID:
23506886
PMCID:
PMC3602789
DOI:
10.1016/j.mam.2012.07.010
[Indexed for MEDLINE]
Free PMC Article

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