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Org Lett. 2013 Apr 5;15(7):1674-7. doi: 10.1021/ol400458n. Epub 2013 Mar 18.

Periconiasins A-C, new cytotoxic cytochalasans with an unprecedented 9/6/5 tricyclic ring system from endophytic fungus Periconia sp.

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1
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, PR China.

Abstract

Periconiasins A-C (1-3), new cytochalasans with an unprecedented 9/6/5 tricyclic ring system, were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated by extensive spectroscopic and X-ray crystallographic analyses. Their biosynthesis is proposed to occur from an unusual seven acetate/malonate polyketide backbone attached to one leucine moiety by a PKS-NRPS followed by Diels-Alder and other reactions. 1 and 2 showed significant cytotoxicity against human HCT-8 cancer cells.

PMID:
23506233
DOI:
10.1021/ol400458n
[Indexed for MEDLINE]
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