Format

Send to

Choose Destination
Expert Opin Drug Discov. 2008 Dec;3(12):1451-60. doi: 10.1517/17460440802580171.

Potential of zebrafish for anticancer drug screening.

Author information

1
Stem Cell Program and Hematology/Oncology, Children's Hospital Howard Hughes Medical Institute Harvard Medical School, Boston, MA 02115, USA +1 617 919 2069 ; +1 617 730 0222 ; zon@enders.tch.harvard.edu.

Abstract

BACKGROUND:

The zebrafish is a powerful vertebrate model organism for large scale genetic and chemical screens.

OBJECTIVE:

With the rapid development of cancer modeling in zebrafish, great opportunities exist for chemical screens to find anticancer agents.

METHODS:

Using embryos, pathway screens can be designed based on our knowledge of cancer biology. Anticancer chemical screens using tumor bearing adult zebrafish facilitate preclinical testing.

CONCLUSION:

Current developments in improving cancer models and automated imaging technology have the potential of finding novel compounds that disrupt tumor biology.

PMID:
23506108
DOI:
10.1517/17460440802580171

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center