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Chem Commun (Camb). 2013 Apr 25;49(32):3339-41. doi: 10.1039/c3cc40383a.

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide.

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1
Biophysics and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.

Abstract

The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been shown to affect this aggregation. A combination of EXAFS, NMR, and AFM experiments shows that the influence of zinc is most likely due to the stabilization of prefibrillar aggregates of hIAPP.

PMID:
23505632
DOI:
10.1039/c3cc40383a
[Indexed for MEDLINE]
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