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PLoS Comput Biol. 2013;9(3):e1002944. doi: 10.1371/journal.pcbi.1002944. Epub 2013 Mar 7.

Collective cell motion in an epithelial sheet can be quantitatively described by a stochastic interacting particle model.

Author information

1
Laboratoire de Physique Statistique, CNRS, Université P et M Curie, Ecole Normale Supérieure, Paris, France. nesepulv@gmail.com

Erratum in

  • PLoS Comput Biol. 2014 Jun;10(6):e1003717.

Abstract

Modelling the displacement of thousands of cells that move in a collective way is required for the simulation and the theoretical analysis of various biological processes. Here, we tackle this question in the controlled setting where the motion of Madin-Darby Canine Kidney (MDCK) cells in a confluent epithelium is triggered by the unmasking of free surface. We develop a simple model in which cells are described as point particles with a dynamic based on the two premises that, first, cells move in a stochastic manner and, second, tend to adapt their motion to that of their neighbors. Detailed comparison to experimental data show that the model provides a quantitatively accurate description of cell motion in the epithelium bulk at early times. In addition, inclusion of model "leader" cells with modified characteristics, accounts for the digitated shape of the interface which develops over the subsequent hours, providing that leader cells invade free surface more easily than other cells and coordinate their motion with their followers. The previously-described progression of the epithelium border is reproduced by the model and quantitatively explained.

PMID:
23505356
PMCID:
PMC3591275
DOI:
10.1371/journal.pcbi.1002944
[Indexed for MEDLINE]
Free PMC Article

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