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Nat Rev Genet. 2013 Apr;14(4):288-95. doi: 10.1038/nrg3458.

Enhancers: five essential questions.

Author information

1
Genomics Division, One Cyclotron Road, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. lapennacchio@lbl.gov

Abstract

It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent researchers in this field look at how much we know already and what needs to be done to answer these questions.

PMID:
23503198
PMCID:
PMC4445073
DOI:
10.1038/nrg3458
[Indexed for MEDLINE]
Free PMC Article
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