Format

Send to

Choose Destination
Nat Med. 2013 Apr;19(4):437-45. doi: 10.1038/nm.3126. Epub 2013 Mar 17.

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia.

Author information

1
Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College, New York, New York, USA.

Abstract

Regulation of erythropoiesis is achieved by the integration of distinct signals. Among them, macrophages are emerging as erythropoietin-complementary regulators of erythroid development, particularly under stress conditions. We investigated the contribution of macrophages to physiological and pathological conditions of enhanced erythropoiesis. We used mouse models of induced anemia, polycythemia vera and β-thalassemia in which macrophages were chemically depleted. Our data indicate that macrophages contribute decisively to recovery from induced anemia, as well as the pathological progression of polycythemia vera and β-thalassemia, by modulating erythroid proliferation and differentiation. We validated these observations in primary human cultures, showing a direct impact of macrophages on the proliferation and enucleation of erythroblasts from healthy individuals and patients with polycythemia vera or β-thalassemia. The contribution of macrophages to stress and pathological erythropoiesis, which we have termed stress erythropoiesis macrophage-supporting activity, may have therapeutic implications.

Comment in

PMID:
23502961
PMCID:
PMC3618568
DOI:
10.1038/nm.3126
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center