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Indian Pediatr. 2013 Aug;50(8):743-7. Epub 2012 Dec 5.

Hypertonic (3%) saline vs 0.93% saline nebulization for acute viral bronchiolitis: a randomized controlled trial.

Author information

1
Department of Pediatrics, SPMCHI, SMS Medical College and Mahatma Gandhi Medical College, Sitapura, Jaipur, Rajasthan Correspondence to: Dr Bhagwan Sahai Sharma, B-2, New Hira Bagh Flats, Near Nurses Hostel, SMS Hospital Campus, Jaipur, Rajasthan 302 004, India. drbssharma@gmail.com.

Abstract

OBJECTIVE:

To compare the length of hospital stay (primary) and improvement in clinical severity scores (secondary) among children with bronchiolitis nebulized with 3 % hypertonic saline or 0.9% saline.

DESIGN:

Randomized double blind controlled trial.

SETTINGS:

Tertiary care teaching hospital.

PATIENTS:

Hospitalized children (1-24 months) with acute bronchiolitis of moderate severity.

INTERVENTION:

Nebulization of 4 ml of 3% hypertonic saline or 4 mL of 0.9% saline, along with 2.5 mg salbutamol, at 4-hourly intervals till the patient was ready for discharge.

RESULTS:

Baseline characteristics were similar in two groups. Median clinical severity score at admission was 6 (IQR-1) in both the groups. Clinical severity scores monitored afterwards 12-hourly till discharge (132 h) did not show statistically significant differences in 3% and 0.9% saline groups. Mean length of hospital stay (time to reach predefined clinical severity score<3) was 63.93 ± 22.43 h in 3% saline group and 63.51 ± 21.27 h in 0.9% saline group (P=0.878). No adverse events were reported by the parents, caregivers or treating medical attendants in both groups.

CONCLUSION:

Nebulized 3 % saline is not superior to 0.9% saline in infants with clinically diagnosed acute bronchiolitis.

PMID:
23502662
[Indexed for MEDLINE]
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