Format

Send to

Choose Destination
See comment in PubMed Commons below
Iran J Immunol. 2013 Mar;10(1):1-9. doi: IJIv10i1A1.

Association between HLA-DQB1*03:01 and Bullous pemphigoid in Iranian patients.

Author information

1
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran Iran, amirzara@tums.ac.ir.

Abstract

BACKGROUND:

A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP.

OBJECTIVE:

To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population.

METHODS:

Fifty patients with Bullous pemphigoid and 180 geographically matched, healthy individuals as control group enrolled into this study. HLA typing of class II (DR and DQ alleles) was carried out using polymerase chain reaction based on sequence-specific primers method.

RESULTS:

Class II DQA1 and DQB1 typing showed a significantly higher frequency of HLA-DQA1*05:01 (45% vs. 33%, p=0.03), HLA-DQB1*03:01 (36% vs. 23.6%, p=0.02) and HLA-DQB1*04:01 (4% vs. 1.6%, p=0.04) in the BP patients compared with controls. For DRB1 allele frequencies, there were no significant disease associations. The frequency of DRB1*08:01/DQA1*05:01/DQB1*03:01 (3% vs. 0%, p=0.02) haplotype showed an increase among patients compared with controls.

CONCLUSION:

Our data suggest that Iranian patients with BP present the same genetic predisposition linked to HLA-DQB1*03:01 previously reported in Caucasians.

PMID:
23502333
DOI:
IJIv10i1A1
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Iranian Society of Immunology and Allergy and Shiraz Institute for Cancer
    Loading ...
    Support Center