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Int J Biol Macromol. 2013 Jun;57:9-16. doi: 10.1016/j.ijbiomac.2013.03.017. Epub 2013 Mar 13.

Effects of β-glucans from Coriolus versicolor on macrophage phagocytosis are related to the Akt and CK2/Ikaros.

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  • 1Department of Life Science, Gachon University, Seongnam 461-701, Republic of Korea.

Abstract

Coriolus versicolor has been known to be an immune stimulator effects. For further understanding of the phagocytic activity and the intracellular mechanisms of β-glucan from C. versicolor (CVG), we examined the phagocytic activity, phosphorylation of Akt and CK2, nucleus translocation of p65 and Ikaros activity in β-glucan-treated macrophages using RT-PCR, western blotting, and IP assay. The role of Ikaros in regulating phagocytic effects of CVG was also determined using Ikaros dominant negative isoform cells. This study suggests that CK2/Ikaros are positive regulators and novel signaling pathway involved in phagocytosis and contributes to elucidating the mechanism underlying phagocytic activity induced by β-glucan.

Copyright © 2013 Elsevier B.V. All rights reserved.

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