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Exp Cell Res. 2013 Jul 1;319(11):1650-6. doi: 10.1016/j.yexcr.2013.03.006. Epub 2013 Mar 13.

Bone marrow cells as precursors of the tumor stroma.

Author information

1
Department of Medicine, Columbia University, NY, USA.
2
II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany.
3
Department of Medicine, Columbia University, NY, USA. Electronic address: tcw21@columbia.edu.

Abstract

Cancer is a systemic disease. Local and distant factors conspire to promote or inhibit tumorigenesis. The bone marrow is one important source of tumor promoting cells. These include the important mature and immature hematopoietic cells as well as circulating mesenchymal progenitors. Recruited bone marrow cells influence carcinogenesis at the primary site, within the lymphoreticular system and even presage metastasis through their recruitment to distant organs. In this review we focus on the origins and contribution of cancer-associated fibroblasts in tumorigenesis. Mesenchymal cells present an important opportunity for targeted cancer prevention and therapy.

KEYWORDS:

Cancer; Carcinogenesis; Fibroblasts; Mesenchyme; Tumor microenvironment

PMID:
23499739
PMCID:
PMC4097986
DOI:
10.1016/j.yexcr.2013.03.006
[Indexed for MEDLINE]
Free PMC Article

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