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Trends Immunol. 2013 Jun;34(6):251-8. doi: 10.1016/j.it.2013.02.005. Epub 2013 Mar 14.

Natural killer cells: walking three paths down memory lane.

Author information

1
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Immunological memory has traditionally been regarded as a unique feature of the adaptive immune response, mediated in an antigen-specific manner by T and B lymphocytes. All other hematopoietic cells, including natural killer (NK) cells, are classified as innate immune cells, which have been considered short-lived but can respond rapidly against pathogens in a manner not thought to be driven by antigen. Interestingly, NK cells have recently been shown to survive long term after antigen exposure and subsequently mediate antigen-specific recall responses. In this review, we address the similarities between, and the controversies surrounding, three major viewpoints of NK memory that have arisen from these recent studies: (i) mouse cytomegalovirus (MCMV)-induced memory; (ii) cytokine-induced memory; and (iii) liver-restricted memory cells.

PMID:
23499559
PMCID:
PMC3674190
DOI:
10.1016/j.it.2013.02.005
[Indexed for MEDLINE]
Free PMC Article

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