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Carbohydr Polym. 2013 Apr 2;93(2):438-41. doi: 10.1016/j.carbpol.2012.12.056. Epub 2012 Dec 27.

Phase transfer-catalyzed synthesis of highly acrylated hyaluronan.

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1
INNOVENT e.V., Biomaterials Department, Prüssingstr. 27B, D-07745 Jena, Germany.

Abstract

Glycosaminoglycans and its derivatives have gained increasing attention for the fabrication of hydrogels usable in biomedicine. Starting from high molecular weight hyaluronan, a natural glycosaminoglycan that forms a mayor component of the native extracellular matrix, we present an efficient phase-transfer-based synthesis for low molecular weight hyaluronan acrylates with a tailored degree of substitution (DS) ranging up to DS values of 1.7. The ability of these compounds to form dimensionally stable hydrogels was proven using different photo-initiator systems.

PMID:
23499080
DOI:
10.1016/j.carbpol.2012.12.056
[Indexed for MEDLINE]
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