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Cell Host Microbe. 2013 Mar 13;13(3):247-9. doi: 10.1016/j.chom.2013.02.012.

RIG-I goes beyond naked recognition.

Author information

1
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.

Abstract

It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors.

PMID:
23498950
DOI:
10.1016/j.chom.2013.02.012
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