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Cell. 2013 Mar 14;152(6):1324-43. doi: 10.1016/j.cell.2013.02.043.

Epigenetics of reprogramming to induced pluripotency.

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1
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner with reprogramming factor binding, transcription, and chromatin states changing during transitions. Evidence is emerging that epigenetic priming events early in the process may be critical for pluripotency induction later. Chromatin and its regulators are important controllers of reprogramming, and reprogramming factor levels, stoichiometry, and extracellular conditions influence the outcome. The rapid progress in characterizing reprogramming is benefiting applications of iPSCs and is already enabling the rational design of novel reprogramming factor cocktails. However, recent studies have also uncovered an epigenetic instability of the X chromosome in human iPSCs that warrants careful consideration.

PMID:
23498940
PMCID:
PMC3602907
DOI:
10.1016/j.cell.2013.02.043
[Indexed for MEDLINE]
Free PMC Article
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