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Cell. 2013 Mar 14;152(6):1270-84. doi: 10.1016/j.cell.2013.02.001.

Genome architecture: domain organization of interphase chromosomes.

Author information

1
MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH42XU, UK. wendy.bickmore@igmm.ed.ac.uk

Abstract

The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.

PMID:
23498936
DOI:
10.1016/j.cell.2013.02.001
[Indexed for MEDLINE]
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