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Cell. 2013 Mar 14;152(6):1237-51. doi: 10.1016/j.cell.2013.02.014.

Transcriptional regulation and its misregulation in disease.

Author information

1
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Abstract

The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.

PMID:
23498934
PMCID:
PMC3640494
DOI:
10.1016/j.cell.2013.02.014
[Indexed for MEDLINE]
Free PMC Article

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