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Trends Immunol. 2013 Jul;34(7):350-9. doi: 10.1016/j.it.2013.02.003. Epub 2013 Mar 13.

MicroRNA-mediated control of macrophages and its implications for cancer.

Author information

1
The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.

Abstract

Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also infiltrated by large amounts of non-neoplastic stromal cells, including macrophages, which express several active miRNAs. Tumor-associated macrophages (TAMs) enhance angiogenic, immunosuppressive, invasive, and metastatic programming of neoplastic tissue and reduce host survival. Here, we review the role of miRNAs (including miR-155, miR-146, and miR-511) in the control of macrophage production and activation, and examine whether reprogramming miRNA activity in TAMs and/or their precursors might be effective for controlling tumor progression.

PMID:
23498847
PMCID:
PMC3700601
DOI:
10.1016/j.it.2013.02.003
[Indexed for MEDLINE]
Free PMC Article

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