Format

Send to

Choose Destination
See comment in PubMed Commons below
Complement Ther Med. 2013 Apr;21(2):98-101. doi: 10.1016/j.ctim.2012.12.010. Epub 2013 Jan 18.

The placebo response in clinical trials-the current state of play.

Author information

1
Department of Psychosomatic Medicine, University Hospital Tübingen, Germany. paul.enck@uni-tuebingen.de

Abstract

While randomized, placebo-controlled double-blinded trials have become the pharmacological standard over the last 60 years, the gain in knowledge of the mechanisms behind the placebo response in recent years has raised substantial concerns about the appropriateness of some of its underlying assumptions. The following questions will be addressed: Is the assumed model of drug and placebo being additive (still) valid? Does the likelihood of receiving active treatment affect the placebo response? What is the size of the placebo response in "active comparator studies"? Minimizing the placebo response/maximizing the drug-placebo difference? How to maximize the placebo response in daily medicine? What is the placebo response with personalized medicines in the future? This and other questions require answers that can only be generated with more experimental studies on the placebo response and with thorough meta- and re-analyses of placebo responses in clinical trials.

PMID:
23497810
DOI:
10.1016/j.ctim.2012.12.010
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center