Format

Send to

Choose Destination
Chem Biol Drug Des. 2013 Oct;82(4):361-6. doi: 10.1111/cbdd.12134.

Synthesis and antimalarial bioassay of quinine - peptide conjugates.

Author information

1
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, 32611-7200, USA.

Abstract

Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine.

KEYWORDS:

amino acid; chemical biology; drug design; peptide

PMID:
23497252
DOI:
10.1111/cbdd.12134
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center