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Expert Opin Med Diagn. 2008 Jun;2(6):677-89. doi: 10.1517/17530059.2.6.677.

Dipeptidyl peptidase-IV and related molecules: markers of malignancy?

Author information

1
Charles University in Prague, Laboratory of Cancer Cell Biology of the 1st Faculty of Medicine, U Nemocnice 5, 128 53, Prague 2, Czech Republic, +420 728 748 692 ; +420 224 965 826 ; aleksi@cesnet.cz.

Abstract

BACKGROUND:

The dipeptidyl peptidase-IV (DPP-IV) family has outgrown its humble origins as a simple enzymatic activity cleaving dipeptides from peptides with an accessible N-terminal penultimate proline with no clear role in metabolism. It is now understood to play a critical role in regulating signaling capacity of chemokines, neuropeptides and other extracellular messengers in addition to playing direct roles by means of non-enzymatic interactions to regulate the local extracellular proliferative environment. Consequently, examination of DPP-IV family representation and activity in immune and oncogenic processes has become a major focus.

OBJECTIVES:

To review the evidence for DPP-IV family members as markers of malignancy.

METHODS:

Overview of published data.

RESULTS/CONCLUSION:

The DPP-IV family, which is probably linked directly to the pathogenesis of cancer, holds significant promise for exploitation in the diagnostic arena.

PMID:
23495778
DOI:
10.1517/17530059.2.6.677

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